Description:
 From Biosynthesis to Total Synthesis: Strategies and Tactics for Natural Products By Alexandros L. Zografos (Ed) Wiley | April 2016 | ISBN-10: 9781118751732 | 584 Pages | PDF | 23.9 mb https://www.amazon.com/Biosynthesis-Total-Synthesis-Strategies-Products/dp/1118751736 Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis. • Describes four major biosynthetic pathways (acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids) and their related mechanisms • Covers reactions, tactics, and strategies for chemical transformations, linking biosynthetic processes and total synthesis • Includes strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications • Acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field CONTENTS PREFACE xv 1 From Biosyntheses to Total Syntheses: An Introduction 1 SECTION I ACETATE BIOSYNTHETIC PATHWAY 19 2 Polyketides 21 3 Fatty Acids and their Derivatives 130 4 Polyethers 162 SECTION II MEVALONATE BIOSYNTHETIC PATHWAY 187 5 From Acetate to Mevalonate and Deoxyxylulose Phosphate Biosynthetic Pathways: an Introduction to Terpenoids 189 6 Monoterpenes and Iridoids 196 7 Sesquiterpenes 236 8 Diterpenes 279 9 Higher Terpenes and Steroids 296 SECTION III SHIKIMIC ACID BIOSYNTHETIC PATHWAY 331 10 Lignans, Lignins, and Resveratrols 333 SECTION IV MIXED BIOSYNTHETIC PATHWAYS: THE STORY OF ALKALOIDS 381 11 Ornithine and Lysine Alkaloids 383 12 Tyrosine Alkaloids 431 13 Histidine and Histidine-Like Alkaloids 473 14 Anthranilic Acid–Tryptophan Alkaloids 502 15 Future Directions of Modern Organic Synthesis 519 INDEX 548 |
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